Seahawks vs. 49ers Picks and Prediction for Saturday, January 3, 2026
On Saturday, the Seattle Seahawks will battle the San Francisco 49ers for the NFC West crown at Levi's Stadium in Week 18 NFL action. We have you ready to go with our Seahawks vs. 49ers prediction, preview, and picks. Kickoff from Santa Clara, CA, is at 8:00 p.m. ET.
The Seahawks are 1.5-point spread favorites, and the game total is 48 points scored.
Seattle leads the all-time series 31-24, but San Francisco has won seven of the last ten (6-4 ATS). The under was 5-4-1 in those games. The Niners beat the Seahawks 17-13 on September 7 in each team's season opener, covering as one-point spread favorites. San Francisco ran 22 more plays than Seattle, dominating the time of possession by nearly 16 minutes. They outgained the home team by over 150 total yards, as the Seahawks were held to three points after the half.
If you want the Seahawks vs. 49ers prediction, read on and check out our NFL Picks to beat the sportsbooks!
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Seahawks are seeking revenge
Seattle (13-3 SU, 11-5 ATS, and 9-7 O/U) beat Carolina 27-10 last weekend, covering the spread as 6.5-point favorites. The Seahawks, who have won six straight games and 10 of their last 11, were 9-for-16 on third down and outgained the Panthers by 149 yards. Carolina was just 1-for-11 on third down and mustered up just 139 total yards, as QB Bryce Young struggled (14-for-24 passing for 54 yards).
Veteran QB Sam Darnold paces the Seattle offense with 3,850 passing yards (240.6 per game) with 25 touchdowns and 14 interceptions. He has completed 67.2 percent of his passes. The USC product's top receiving targets are WRs Jaxon Smith-Njigba (113 receptions for 1,709 yards and ten TDs) and Cooper Kupp (45 receptions for 564 yards and two scores). Michigan State product Kenneth Walker III leads the Seahawks on the ground with 205 carries for 930 yards and five touchdowns.
Seattle scores 29.4 points per game (2nd) and averages 350.8 total yards (9th), including 231.0 passing yards (9th) and 119.8 rushing yards (16th). The Seahawks defense surrenders 18.1 points (2nd) and 292.9 total yards (6th) per game, including 198.6 passing yards (12th) and 94.4 rushing yards (3rd).
Seattle Seahawks Injury Report:
- S Coby Bryant (knee), WR Rashid Shaheed (concussion), G Josh Jones (ankle/knee), and OT Charles Cross (hamstring) are questionable to play against the 49ers.
49ers won't need to leave Santa Clara if they win out
San Francisco (12-4 SU, 10-6 ATS, and 10-5-1 O/U) held off Chicago at home on Sunday night, winning 42-38 as 4.5-point favorites. The 49ers gained nearly 500 total yards, averaging 7.3 yards per play, as they were a combined 8-for-11 on third and fourth down. They were also 5-for-5 in the red zone.
QB Brock Purdy leads the Niners' passing attack with 2,040 yards, 20 touchdowns, and nine interceptions in eight games. He has completed 69.3 percent of his passes, averaging 7.9 yards per attempt. Purdy's top receiving targets are RB Christian McCaffrey (96 receptions for 890 yards and seven TDs) and WR Jauan Jennings (51 receptions for 608 yards and nine TDs). The Stanford product McCaffrey also leads San Francisco in rushing (303 carries for 1,179 yards and ten TDs).
The 49ers score 27.1 points per game (8th) and average 362.6 total yards (7th), including 252.3 passing yards (4th) and 110.3 rushing yards (23rd). The San Francisco defense surrenders 22.4 points (13th) and 338.9 total yards (19th) per game, including 235.6 passing yards (25th) and 103.3 rushing yards (6th).
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San Francisco 49ers Injury Report:
- TE George Kittle (ankle), RB Christian McCaffrey (back), OT Trent Williams (hamstring), WR Ricky Pearsall (ankle/knee), FB Kyle Juszczyk (hip), DE Yetur Gross-Matos (knee), Keion White (groin), and CB Upton Stout (concussion) are questionable to play against the Seahawks.
Seahawks vs. 49ers Pick and Preview
Spread Pick for Seahawks vs. 49ers
- Seattle -1.5 (5 Units)
San Francisco won the first matchup between these division rivals back in Week 1, but I'm confident Seattle will get the last laugh. The Seahawks' defense will be the difference, as they are talented enough to neutralize the impact of the 49ers' elite play-caller, Kyle Shanahan. While the home team has excelled offensively over the last four weeks, they faced just one defense ranked in the top ten in EPA (Cleveland) during that stretch. Both Seattle and San Francisco have won six straight games, but the Niners' record is boosted by their weak strength of schedule.
The Seahawks limited McCaffrey to just three yards per carry in Week 1 and have recently held Jonathan Taylor and Bijan Robinson to under 90 yards. They rank second in rushing success rate allowed this season. While Purdy has been excellent lately, he will be under pressure from a Seattle pass rush unit ranked fifth in win rate this season. On the other side of the ball, don't expect the 49ers to have similar success pressuring Darnold. They rank 29th in pass-rush win rate and last in sacks, as the losses of Nick Bosa and Fred Warner have been evident. With enough time to go through his reads, Darnold plays like a top-ten QB.
Seattle is 11-4 ATS in its last 15 games. While the Niners have owned this rivalry series recently, I recommend backing the Hawks to cover as 1.5-point favorites on Saturday in Santa Clara.
Over/Under Pick for Seahawks vs. 49ers
- Under 48 (4 Units)
The over has been the winning wager in both teams' games this season, but I recommend betting on the under at 48. The Seahawks' defense ranks first in opponent yards per pass and rush and second in total EPA this season. They get after the quarterback and limit explosive plays better than any team in the NFL. They can contain the banged-up McCaffrey and pressure Purdy, making the 49ers' offensive attack look more pedestrian. While I have concerns that the 49ers' defense will struggle to contain the Seahawks' offense, I don't anticipate a shootout. Plus, if they can build a lead, the visitors will play more conservatively to run down the game clock in the second half.
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