Tampa Bay Buccaneers vs. Buffalo Bills, Odds, Preview, Picks and Prediction, Sunday, November 16, 2025

Tampa Bay (6-3) will be going for their second consecutive road win when they visit Highmark Stadium on Sunday afternoon to face Buffalo (6-3) at 1 PM. ET. Read on to find out which team picks up the win in this Buccaneers vs. Bills prediction. When it comes to pro football picks, our NFL Predictions are stellar.

The Buccaneers are coming off a 28-23 loss to New England as 2.5-point favorites. The Bills are coming off a 13-10 loss to Miami as eight-point favorites.

Tampa Bay is 6-4 in its last 10 games against Buffalo. The Bills won the last meeting in 2023, 24-18.

Buccaneers Trying To Bounce Back From Loss

The Buccaneers followed up their win over the Saints with a loss to the Patriots in their last game. They will try to bounce back from the loss and pick up their second win in their last three games when they play on Sunday.

Tampa Bay averages 24.4 points per game, which is 11th in the league. They throw for 228.6 yards and rush for 99.8 yards per game.

Baker Mayfield has completed 64 percent of his passes for 2,192 yards, 16 touchdowns, and two interceptions. Rachaad White has 87 carries for 325 yards and four touchdowns, while Emeka Egbuka has 40 catches for 677 yards and six touchdowns.

Tampa Bay is giving up 22.9 points per game, which is 14th in the league. They’re giving up 233.2 passing yards and 100.8 rushing yards per game.

Key Injury Report for Buccaneeers

• LB-Hasson Reddick (Knee) is out
• OG Ben Bredeson (hamstring) is out
• WR Chris Godwin Jr. (fibula) is out
• RB Bucky Irving (foot/shoulder) is out
• WR Mike Evans (broken collarbone) is out 6-8 weeks.

Buffalo Going For Third Win In Four Games

The Bills had their two-game winning streak snapped by the Dolphins in a surprising loss, dropping them one game behind New England in the AFC East standings. They will try to bounce back from the loss and pick up their third win in their last four games when they play on Sunday.

Buffalo averages 27.6 points per game, which is sixth in the league. They throw for 231.2 yards and rush for 153.2 yards per game.

Josh Allen has completed 70 percent of his passes for 2,139 yards, 15 touchdowns, and five interceptions. He also has 311 rushing yards and seven touchdowns. James Cook leads the team with 166 carries for 920 yards and seven touchdowns, while Khalil Shakir has 45 catches for 457 yards and three touchdowns.

Buffalo is giving up 21.9 points per game, which is 11th in the league. They’re giving up 170.2 passing yards and 147.6 rushing yards per game.

Injuries: WR-Khalil Shakir (Ankle), LB-Terrel Bernard (Ankle). DB-Cam Lewis (Calf), DE-Joey Bosa (Wrist), and CB-Dorian Strong (Neck) are questionable for this game.

Key Injury Report for Bills:

• DT Phidarian Mathis (shoulder) is out
• CB Cam Lewis (calf) is questionable.
• DT TJ Sanders (knee) is questionable.
• CB Taron Johnson (groin) is questionable
• LB Shaq Thompson (hamstring) is questionable
• TE Dalton Kincaid (hamstring) is out.

Buccaneers vs. Bills Picks

Point Spread Pick for Bucs vs. Bills

• Buffalo Bills -5.5 (4 Units)

The Bills have won four of their five home games, while the Buccaneers have won three of their last five games. Buffalo has the edge here because they have one of the best offenses in the league and can beat opponents through the air and on the ground. The Bucs have a good run defense, but their secondary isn’t very good, with the team giving up more than 230 passing yards per game, so expect them to have a hard time slowing down the Bills.

Tampa Bay will have a hard time keeping up in this game because they don’t run the ball well and rely heavily on their passing game. The Bills aren’t great against the run, but they have the third-best pass defense in the country, so expect them to keep Tampa Bay’s offense in check. Go with Buffalo to cover the spread.

Over/Under Pick for Buccaneers vs. Bills

• Under 47 (4 Units)

Tampa Bay averages 24.4 points per game. They throw the ball 59 percent of the time with the 14th-ranked passing attack in the league, and they’re facing a team that is third against the pass and is giving up 21.9 points per game. The Bills average 27.6 points per game. They throw the ball 51 percent of the time with the 12th-ranked passing attack in the league, and they’re facing a team that is 24th against the pass and is giving up 22.9 points per game. Don’t expect these teams to score enough points to push the score over the total.