Thursday Night Football Player And Team Props For Seahawks vs Cardinals

By: Dean Whitaker Updated 09/25/2025, 02:01 PM ET
Sam Darnold looks to lead the Seahawks over the Cardinals
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The week kicks off with a massive NFC West showdown as the Seattle Seahawks take on the Arizona Cardinals under the Thursday night lights. This divisional clash is loaded with betting potential, and we’ve zeroed in on three of the strongest prop bets available.

Each selection is supported by player usage trends, matchup data, and recent performance, giving bettors a sharp edge. Don’t miss the chance to cash in on tonight’s primetime action.

Top TNF Prop Bets Today

  • Sam Darnold 220+ Yards Passing (-136)
  • Each Team To Throw At Least 1 Passing TD (-130)

  • Arizona Over 19.5 Points Scored (-155)

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Odds courtesy of DraftKings Sportsbook

TNF Best Bet #1: Sam Darnold To Have 220 Or More Passing Yards

Sam Darnold is primed to clear the 220-yard mark tonight against Arizona, thanks to a favorable matchup and a surging Seattle offense. The Cardinals rank bottom-10 in opponent completion percentage and have allowed 250+ passing yards in four of their last five games. Darnold has averaged 9.1 yards per attempt over his last two starts and benefits from a clean pocket behind an improving offensive line.

With Jaxon Smith-Njigba emerging as a reliable deep threat and Kenneth Walker keeping defenses honest on the ground, Darnold should have ample opportunity to attack soft zone coverage and rack up yardage through play-action and intermediate throws. Expect a stat line in the range of 23-for-32, 245 yards, and a touchdown.

Also see: Seattle vs Arizona Prediction

TNF Best Bet #2: Each Team will Have at Least 1 Passing TD

Tonight’s Seattle–Arizona matchup sets up well for both teams to notch at least one passing touchdown. Sam Darnold has thrown for multiple scores in back-to-back games and faces a Cardinals defense that ranks bottom-10 in red zone coverage and has allowed 2+ passing TDs in four of its last five outings. With Jaxon Smith-Njigba and DK Metcalf stretching the field, Seattle’s vertical game is primed to strike.

On the other side, Kyler Murray remains a dual-threat weapon and has thrown at least one touchdown in six straight home starts. Seattle’s defense is stout but has shown vulnerability against mobile quarterbacks who extend plays. With Trey McBride and Rondale Moore working underneath and Marquise Brown capable of breaking loose, Arizona has enough firepower to find the end zone through the air. Expect both teams to hit the board via the pass, making this prop a strong candidate to cash.

TNF Best Bet #3: Arizona Over 19.5 Points Scored

Derrick Henry Over 87.5 rushing yards is a high-upside prop in tonight’s Ravens–Lions clash, especially given his volume and matchup. Henry is averaging 96.0 yards per game this season and has already cleared this number once, torching Buffalo for 169 yards on 18 carries in Week 1.

Detroit’s run defense ranks 21st in the NFL, allowing 106 rushing yards per game, and they’ve struggled to contain power backs—giving up 134 yards to Chicago last week. With Baltimore leaning heavily on the ground game and Henry seeing 14.5 carries per game, the workload is there. Add in home-field advantage and a projected close game script, and Henry should have every opportunity to grind past this number.

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