St. Louis Blues vs Buffalo Sabres Picks and Prediction for Thursday, November 6, 2025
Use Code WWWC The St. Louis Blues (4-7-2, 10 points, 8th Central) play the back-half of a back-to-back on Thursday when visiting the Buffalo Sabres (5-4-4, 14 points, T-5th Atlantic) after playing on the road Wednesday night against the Washington Capitals. St. Louis beat Edmonton 3-2 last time out to snap a seven-game losing streak. The Blue are last in the Central division. Buffalo lost to the Utah Mammoth on Tuesday, 2-1, and has lost four of the last six. The Sabres are in a three-way tie for fifth in the Atlantic Division. St. Louis will play without Zach Dean, Jake Neighbours, and Torey Krug. Buffalo will play without Jason Zucker, Jiri Kulich, Zach Benson, Carson Meyer, Justin Danforth and Josh Norris. Make sure to read this in-depth St. Louis Blues vs Buffalo Sabres prediction. Hockey fans, lace up! Explore our NHL picks for the St. Louis Blues at Buffalo Sabres prediction and score big on the ice.
This article was written before St. Louis played on Wednesday.
St. Louis is below average on attack, and has the league’s worst defense
The St Louis Blues have a goals-for average of 2.8 and a goals-against average of 4.0, which are 21st and 32nd or last, respectively. St Louis averages the 21st most shots per game at 27.3 and holds opponents to an average of 25.6, which is 7th. The St Louis power play is 10th, scoring 25.0% of the time, while the penalty kill is 28th, holding opponents scoreless 67.6% of the time.
Jake Neighbours leads St Louis in goals scored with six, but is out injured. Pius Suter is second in goals scored with five and tied for the lead in points with three others at 8. Robert Thomas is the leader in assists with six and one of four with a team-best 8 points. St Louis has scored nine goals on the power play in 13 games. Suter is the leader in plus/minus at 2. Starting goalie Jordan Binnington has played in 10 games to just five by backup Joel Hofer. Binnington is 3-4-2 with a 3.08 goals against average and a .868 save percentage.
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Buffalo needs improvement at both ends of the ice
The Buffalo Sabres have a goals-for average of 2.8 and a goals-against average of 3.1, which are 20th and 19th, respectively. Buffalo's power play is 9th in the NHL, converting 29.5% of the time the Sabres have the man advantage, while the penalty kill is first, holding opponents scoreless 90.9% of the time Buffalo is shorthanded.
Alex Tuch (5 goals, 7 assists) leads Buffalo in points with 12, and Tage Thompson is second in points with 10 (5 goals, 5 assists). Two others are tied for third in points with nine each. Rasmus Dahlin is the leader in assists with 8. Buffalo has scored eight goals on the power play in 13 games. Mattias Samuelsson is the leader in plus/minus at 3. Alex Lyon has been between the pipes for 10 of Buffalo's games. Lyon is 3-4-3 with a 2.81 goals against average and a .915 save percentage. Ukko-Pekka Luukkonen is off the injured list but has played in just two games at 1-0-1, with a 3.34 GAA and .877 SV%.
St. Louis Blues vs. Buffalo Sabres Pick
Spread Pick for Blues vs. Sabres
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Buffalo Sabres (4 units)
The St Louis Blues will be coming off a game on the road Wednesday night versus Washington when visiting Buffalo on Thursday. St Louis has struggled to put the puck in the net, averaging 2.8 goals per game and has had plenty of problems keeping the puck out of their own net, as the Blues have a 4.0 goals against average. Part of the St Louis problem is the Blues are 28th in the penalty kill at 67.6% and will face a Buffalo team that is 19th on the power play, giving Buffalo a slight advantage. Buffalo’s penalty kill is the NHL's best at 90.9% and will quiet the St Louis power play, which is 10th at 25%. Ukka-Pekka Luukkonen is back for Buffalo after missing several games to start the season and has a 3.34 GAA, but Alex Lyon has performed well in 10 games for the Sabres with a 2.81 GAA. St Louis has lost seven of its last eight. Buffalo has won five of its last seven played at home.
Over/Under Pick for Blues vs Sabres
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Over (4 units)
The total has finished over in five of Buffalo's last six games. The total has finished over in 13 of St Louis’ last 18 games and in six of the last seven games that St Louis has played on the road. St Louis is last in the NHL in goals against, at 4.0 per game, and Buffalo is only slightly better at 3.1 goals against per game, which is 19th. Buffalo is giving up the second-most shots per game at 32.3.
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