Philadelphia Phillies vs. Los Angeles Dodgers Picks and Prediction for Tuesday, September 16, 2025
Use Code WWWC Philadelphia Phillies (89-61) vs. Los Angeles Dodgers (84-65)
The 2025 Major League Baseball season continues Tuesday, September 16, with the Philadelphia Phillies squaring off against the Los Angeles Dodgers in the National League showdown at Dodger Stadium in Los Angeles, CA, so here’s our Phillies vs. Dodgers prediction and the latest odds update.
Philadelphia and Los Angeles continue their three-game series in California, and Monday’s opener has been excluded from the analysis. This article was published before Monday’s results. The Phillies met the Dodgers in April, when Philadelphia took two out of three games against the reigning World Series champions.
Let’s take a closer look at this Phillies vs. Dodgers prediction, one of our MLB picks for Tuesday’s slate. The first pitch at Dodger Stadium is set at 10:10 PM ET, and the hosts are -115 moneyline favorites with a total of 8.0 runs.
The Phillies continue to chase the Brewers
The Philadelphia Phillies ended their six-game winning streak last Sunday, suffering a 10-3 defeat to the Kansas City Royals. Despite the loss, the Phillies clinched the playoff berth and were one win away from securing the NL East title. Philadelphia was just two games behind the Milwaukee Brewers, as these two teams continue their race for the best record in baseball.
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The Phillies have gone 9-2 in their previous 11 games overall. During that stretch, the Phillies have scored 65 runs on a sturdy .305/.372/.537 triple-slash, while their bullpen has recorded a 4.35 ERA, 1.32 WHIP, and a .254 batting average against.
Cristopher Sanchez is expected to toe the slab at Dodger Stadium on Tuesday night. The 28-year-old left-hander is 13-5 with a strong 2.57 ERA and 1.11 WHIP in 29 starts (182.1 innings pitched) this season. He’s allowed an earned run in each of his previous three outings.
Sanchez will meet the Dodgers for the second time this season. Back in April, he threw 5.2 innings in a no-decision against the Blue Crew, allowing four earned runs on six hits and a walk. Sanchez is 2-0 with a 3.57 ERA in three career starts against the Dodgers, who are 19-for-74 with four doubles and three home runs against him.
The Dodgers lead the way in the NL West
The Los Angeles Dodgers trounced the San Francisco Giants 10-2 this past Sunday to clinch a three-game series at Oracle Park in San Francisco. After a 5-1 extra-inning loss in the opener, the Dodgers have accounted for 23 runs in the next two games. They were topping the NL West on Monday morning, 2.5 games ahead of the San Diego Padres.
The Dodgers started the month of September with a five-game losing streak. Since then, the Dodgers have gone 6-1 while scoring 48 runs on a strong .302/.374/.488 slash line. During that seven-game stretch, the Dodgers ‘pen has compiled a 3.43 ERA, 1.19 WHIP, and a .182 batting average against.
Shohei Ohtani is projected to get the starting call on Tuesday, and the 31-year-old right-hander carries a 1-1 record with a 3.75 ERA and 1.19 WHIP in 12 starts (36 innings pitched) in 2025. Since a meltdown at Coors Field on August 20, Ohtani has only allowed one earned run on five hits and three walks across two starts and 8.2 innings of work.
Ohtani will pitch against the Phillies for the first time in his career. Five guys from this Philadelphia team have seen Ohtani before, combining for two doubles and a single in 14 at-bats.
Phillies vs. Dodgers Pick
Moneyline Pick for Phillies vs. Dodgers
- Los Angeles Dodgers (5 units)
This series is a joy to watch, but it’s hard to pick a winner. We will see a couple of great starting pitchers on Tuesday night, and I will take the Dodgers only because they already got to Cristopher Sanchez early in the season.
A lot of guys from the Phillies’ lineup will see Shohei Ohtani for the first time. Ohtani won’t pitch deep into this game, but he could easily dominate the Phillies through the first four or five innings. The Dodgers' bullpen has struggled for most of the season, but it has pitched well over the last eight days.
Over/Under Pick for Phillies vs. Dodgers
- Over 8.5 (5 units)
Both lineups have done a great job over the last 10 days. During that span, the Phillies have recorded a 166 wRC+ against the righties and a 138 wRC+ against the lefties, while the Dodgers have accounted for a 124 wRC+ versus the righties and a 139 wRC+ against the lefties.
Hereof, give me the over. Cristopher Sanchez will have a tall task to extend his strong run of form. As I noted, Sanchez struggled against the Dodgers in April. On the other side, Shohei Ohtani should fare well, but the Dodgers will have to lean on their bullpen in this game.
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