New York Mets vs. Minnesota Twins Prediction and Picks - April 16, 2025

Author: Bosun Akinpelu Last Updated: April 16, 2025 Game Start: 1:10pm EST

New York (11-5) will be going for the series win when they visit Target Field on Wednesday afternoon to face Minnesota (5-12) in the final game of their three-game interleague series at 1:10 PM. ET. Read on to find out which team picks up the win in this Mets vs. Twins prediction, and check out our MLB Betting Picks.

Griffin Canning, 1-1, 4.20 ERA, will get the start for the Mets. The Twins will counter with David Festa, 0-0, 0.00 ERA.

New York is 7-3 in its last 10 games against Minnesota.

**This preview was written before Tuesday's game was played.**

New York Going For Fifth Consecutive Series Win

The Mets have been on a roll since their series split with Houston, winning their last four series. They took the lead in the first game and will try to pick up their fifth straight series win when they play on Wednesday.

New York averages 4.13 runs per game, which is 16th in the league. Their .214 batting average is 23rd in the league. Their .300 on base percentage is also 23rd, while their .367 slugging percentage is 19th.

Pete Alonso leads New York with a .345 batting average and 19 RBI, while Brandon Nimmo leads the team with four home runs.

New York is giving up 2.19 runs per game,. which leads the league. Opponents have a .211 batting average against the Mets, which is fifth in the league. Their 2.22 ERA leads the league, while their 1.16 WHIP is eighth.

In his last start, Canning gave up seven hits and four runs in 5.1 innings, leading to a 7-6 win over the Athletics. He is 0-2 with a 15.26 ERA in two games against Minnesota.

Jose Siri *Fibula) is questionable for this game.

Minnesota Trying To End Slump

The Twins haven't had much go their way so far this season and they've lost their last three series. They will try to turn things around and try to avoid losing their fourth straight series when they play on Wednesday.

Minnesota averages 3.29 runs per game, which is 27th in the league. Their .203 batting average is 27th in the league. Their .274 on base percentage is also 27th, while their .327 slugging percentage is 25th.

Ty France leads Minnesota with a .288 batting average. Byron Buxton leads the team with three home runs, while Harrison Bader leads the team with 10 RBI.

Minnesota is giving up 3.71 runs per game, which is 14th in the league. Opponents have a .237 batting average against the Twins, which is 16th in the league. Their 3.86 ERA is 15th, while their 1.21 WHIP is 12th.

In his last start, Festa gave up three hits and one run in 4.2 innings, leading to a 7-6 loss to Detroit. He is 0-1 with a 3.60 ERA in one start against New York.

Best Bets for New York Mets vs. Minnesota Twins

Full-Game Side Bet

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The Twins have lost three of their last four games, while the Mets have won four of their last six road games. Even though they're not playing well at the moment, the Twins have the edge here because they hit the ball better against right-handers, and Canning has struggled on the road, giving up six runs in two road starts. He gave up 14 runs in two starts against the Twins and will have a hard time slowing them down. The Mets won;t be as successful offensively because they haven't hit the ball well against right-handers and Festa looked good in his first start, giving up only one run. He gave up two runs in his lone start against the Mets and will keep their offense in check. Go with Minnesota to cover the money line.

Prediction: Minnesota Twins ML

Full-Game Total Pick

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The Mets played over the total in three of their last six games. New York averages 4.13 runs per game and averaged 4.67 runs per game in their last three games. They're batting .210 against right-handers and they're facing a starter who gave up two runs in his lone start against them. The Twins average 3.29 runs per game and averaged two runs per game in their last three games. They're batting .225 against right-handers and they're facing a starter, who gave up four runs in his last start and nine runs in his last start against the Twins. Expect these teams to score enough points to push the score over the total.

Prediction: Over
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Bosun Akinpelu , "Bosun Akinpelu"

Bosun is very passionate about sports and he feels bad to get paid for doing this, but we here at Winners and Whiners are glad to have him as a part of the team. As someone who minored in Mathematics, Bosun has a lot of faith in numbers and will make his picks based on stats and not emotions. He has been successfully picking and betting on winners for quite some time, so if you want to crush the books, then stick with Bosun.