Prediction, Preview, and Odds
#1973 San Diego Padres vs.
#1974 Los Angeles Dodgers
Thursday, April 22, 2021 at 10:10pm EDT
Written by David Delano

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The Los Angeles Dodgers will host one of their NL West rivals, the San Diego Padres, on Thursday night. The Dodgers took two of the three head-to-head games that these teams played against each other over the weekend.

The San Diego Padres lost to the Milwaukee Brewers 4-2 on Wednesday for their third straight loss. The Los Angeles Dodgers were off on Wednesday after splitting a two-game road series against the Seattle Mariners.

According to DraftKings, the Padres currently have the second-best odds to win the NL West at +285 behind the Dodgers, who are commanding -400 favorite.

Weathers faces Dodgers for the second straight time

The abbreviated 2020 season was filled with excitement for San Diego fans. The Padres went 37-23 during the regular season and advanced to the playoffs for the first time since 2006. In the postseason, the Padres took 2 out of three games from St. Louis in the League Wild Card Series before being swept in three games by the Dodgers in the League Divisional Series. After being swept at home against Milwaukee, the Padres are 10-10 overall.

As a team, San Diego is 14th in baseball, batting .233, 26th averaging 3.6 runs per game, and 25th hitting 0.90 home runs per game. Eric Hosmer leads the team with a .319 batting average and 14 RBI. Hosmer is also tied with three other Padres with club three home runs.

The Padres are allowing 3.4 runs per game, which is the fifth-best in MLB. Rookie south-paw Ryan Weathers is scheduled to make a start on Thursday. Weathers is 1-0 with a 0.93 ERA and 0.72 WHIP on the season in four games and one start. Weathers tossed 3 2/3 innings (the longest outing of his career) of scoreless baseball, allowing one hit and two walks in his start against the Dodgers on Friday.

Dodgers undefeated at home

After winning the World Series in 2020, the Dodgers have picked up right where they left off, jumping out to an MLB best 14-4 record to start the season. Los Angeles has been getting it done in every area of the game. The Dodgers are fourth in baseball, averaging 5.2 runs per game, fifth batting .248, and ninth hammering 1.3 home runs per game. The Dodgers dominant start has come even without one of their franchise players, Cody Bellinger, who has only played four games this year and is currently out indefinitely with a leg injury.

Leading the way for Los Angeles has been the third baseman Justin Turner, who is off to an MVP caliber start, with a .444 on-base percentage, 381 batting average, five home runs, and 16 RBI. Turner went 4 for 13 with one home run and two RBI against the Padres last weekend. He is also batting .556 at home with three home runs and seven RBI in six games this season.

Making a start for LA on Thursday will be Walker Buehler, who is 1-0 with a 2.00 ERA in three starts so far this season. Last Friday, Buehler allowing two earned runs and seven hits in six innings of work, which resulted in an 11-6 Dodgers win over the Padres in 12 innings. Buehler is 4-0 with a 1.62 ERA and 0.82 WHIP in his career against the Padres.

Best Bets for this Game

Full-Game Side Bet

Insiders Status:


The Los Angeles Dodgers are a perfect 6-0 at home this season and will be sending Walker Buehler to the hill, who has dominated the Padres in six career starts. Buehler has also been excellent at Dodger Stadium in his career, where he's made 31-lifetime regular-season starts and is 12-4 with a 2.39 ERA and 0.87 WHIP. The Padres are a very talented team, but they have struggled recently against winning ball clubs. The Padres have definitely had their issues with the Dodgers recently, with Los Angeles taking seven out of the last eight games in this rivalry. Los Angeles has also won 14 straight games at Dodger Stadium dating back to the 2020 post and regular seasons. I will back the best team in baseball on Thursday and go with the Dodgers.

Prediction: Los Angeles Dodgers ML -173

Full-Game Total Pick

Insiders Status:


The Dodgers and Padres have both been excellent plays against the under this season, with 68% of the Padres games and 67% of Dodgers games going below the total.  Including the playoffs,  Walker Buehler has never allowed more than three earned runs in a start against the Padres. I expect Buehler to have another great outing here, as he faces a Padres lineup that has two runs or less in three-straight games. His counterpart Ryan Weathers has never gone a full four innings in a big-league game yet, but he has been sharp thus far and will be followed up by a Padres' bullpen that has a 2.45 ERA, the third-best in baseball.  Both of these teams have also played well defensively, with San Diego second in MLB with 11 defensive runs saved on the season, and the Dodgers are 12th with three defensive runs saved. I like the under in this contest.

Prediction: Under 8

Written By David Marotta , "David Delano"

David Delano is a Bowling Green State University graduate with a passion for sports, traveling, and music. David loves to handicap MLB, NFL, NCAAF, NCAAB, NBA, WNBA, and is also a big fan of boxing and track and field. Over the years, David has worn several hats in the sports world, from being behind the camera to writing, filming, editing, scouting, and coaching, along with servicing his clients as a sports handicapper.  We are glad to have David on our team, so be sure and follow along.