Prediction, Preview, and Odds
#2957 San Francisco Giants vs.
#2958 Colorado Rockies
Wednesday, September 21, 2022 at 8:40pm EDT
Written by Adam Rauzino

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The San Francisco Giants (70-77, 68-79 RL, 69-70-8 O/U) and the Colorado Rockies (64-83, 80-66 RL, 67-72-7 O/U) continue a four-game divisional series on Wednesday evening. The Giants will send Logan Webb to the hill. The Rockies give the nod to German Marquez, eying his ninth victory. The Giants lead the season series 9-5, after winning 6-3 on Tuesday.

Webb Targets Third Win of September

The Giants will give Logan Webb the nod on Wednesday night. Webb did not have his best stuff last time out, conceding four runs on seven hits in four innings against the Cubs, and was tagged with the loss to dip to 13-9. The young right-hander continues to excel, allowing two or fewer runs in four out of his last five outings, and is sporting a 3.02 ERA and a 1.19 WHIP in 182 innings pitched. Webb has allowed six runs (five earned) in 12.2 innings against Colorado this season and is 4-2 with a 4.32 ERA in 50 career innings against the rivals. 

San Francisco was tagged with a sweep by the Dodgers last weekend but has won two out of their last three series including a triumph against the Braves. The Giants have won three consecutive road games entering Tuesday after a 10-7 win in the series opener.

Thairo Estrada has been feasting on the Rockies pitching, hitting a dazzling .400 with 10 RBIs. The 26-year-old second baseman is having a breakout season, delivering 14 homers with 58 RBIs and a .742 OPS. Estrada has seven RBIs and a strong .889 OPS on the month.

The Giants are scoring an average of 4.37 runs on the year, landing them 16th overall. The pitching staff is carrying a 3.88 team ERA, placing them 11th in the big leagues. 

Marquez Starts, Rockies Shine at Home

German Marquez will be on the hill in this one. Marquez rebounded from a bad outing by limiting the Cubs to only two runs in seven innings last weekend, but didn’t get much help and took the loss to bring his record to 8-11. The veteran right-hander has been fairly consistent in the last month or so but has filed a 5.14 ERA and a 1.38 WHIP in 164.2 innings pitched on the year. Marquez conceded three runs on four hits in six innings against the Giants in the only meeting this season and has amassed a poor 6.98 ERA and a 5-8 record against the foes. 

Colorado has won each of its last three home series and now stands at five games above .500 at Coors Field. They won two of three road bouts against the Cubs prior to this series, limiting them to only six runs.

CJ Cron has not been able to solve the Giants' pitching this year, driving in only seven runs along with a .630 OPS. The 32-year-old first baseman is having a fantastic season, bashing 28 homers with 98 RBIs and an .801 OPS. Cron has four homers and 12 RBIs this month.

The Rockies are posting 4.45 runs per game, landing them 12th overall. The pitching staff brings a 5.04 team ERA, pegging them 30th in the Major Leagues. 

Best Bets for this Game

Full-Game Side Bet

Insiders Status:


The Giants always have a good chance when Logan Webb is on the mound. Webb is steady, allowing two or fewer runs in four out of his last five starts, and held the Rockies to only three runs in seven innings in his lone performance at Coors Field this season.

Furthermore, the Giants will generate offense against Rockies’ starter German Marquez. The veteran has surrendered a whopping 15 runs in his last two starts at Coors Field and has a 6.78 ERA in that park this season. Marquez has not been able to contain the Giants at all, logging an abysmal 6.78 career ERA against the rivals.

Prediction: San Francisco Giants -140

Full-Game Total Pick

Insiders Status:


I expect a barrage of runs. This should be another wild high scoring game. The Giants have exploited the Rockies pitching, averaging a stellar 5.92 runs in the 13 meetings.

In addition, the Rockies' offense is much better at Coors Field and has averaged 4.70 runs against the Giants this season. They have enjoyed success against Webb as the young pitcher has a 4.32 ERA in 50 innings against the foes. The over is 6-1 in the Rockies' last seven home games against a team with a losing record.

Prediction: Over 10

Written By Adam Rauzino , "Adam Rauzino"

Adam has been a sports fanatic his entire life, closely following hockey, baseball, basketball, and football. He enjoys analyzing various stats, as well as studying Sabermetrics and analytics to take his picks to a whole new level. Adam has a passion for writing about various sports as well as personal finance and being an expert sports bettor. Prior to bringing his talents here to Winners and Whiners, Adam graduated with a diploma in business marketing and business finance. You would do yourself a huge favor by following Adam on a daily basis.