Prediction, Preview, and Odds
#2921 Chicago White Sox vs.
#2922 Cleveland Indians
Friday, September 24, 2021 at 7:10pm EDT
Written by David Delano

This article covers a past game!

View upcoming games.

The Cleveland Indians will host the Chicago White Sox in the third contest of a five-game series on Friday. On Thursday, these two teams split a doubleheader, with the White Sox winning the first game 7-2 and the Indians winning the second game 5-3.

This season series has been dead-even with each team winning eight of the 16 head-to-head games so far.

White Sox have struggled on the road

The Chicago White Sox have clinched the AL Central with a 86-67 record and are currently in line to be the third seed in the American League playoffs. Chicago has an American League-best 49-27 record but is a losing road team with a 37-40 mark.

Chicago ranks third in MLB with a .335 on-base percentage, and seventh scoring 4.9 runs per game. Leading the lineup in power individually is Jose Abreu, with 29 home runs and 113 RBI. Tim Anderson leads the team with a .306 batting and 17 stolen bases, and 16 home runs, and 58 RBI. On Monday, Anderson hit two home runs and drove in four in the White Sox 7-2 opening game win.

The White Sox pitching staff ranks is sixth with a 3.77 team ERA and sixth with a 1.21 WHIP, and Dylan Cease will start on Friday. In 30 starts this year, Cease is 12-7 with a 4.09 ERA. This year, Cease has only faced the Indians and allowed eight hits and six earned runs in 3 1/3 innings of a 6-5 loss on June 1.

Indians looking to get back to .500

The Cleveland Indians are 75-77 on the season, holding a game lead over the Detroit Tigers for second place in the AL Central. Cleveland is 18th with 4.4 runs scored per game and 23rd with a .237 batting average. Cleveland is led by Jose Ramirez, who has a team-best 6.4 WAR, 35 home runs, 96 RBI, and 24 stolen bases.

On Friday, the Indians will start the reigning AL Cy Young winner Shane Bieber. Bieber will be looking to end the year with some positive momentum after not pitching since June 13 due to being sidelined with a strained rightsholder. In 14 starts earlier this year, Bieber went 7-4 with a 3.28 and 1.25 WHIP. In 11 career starts against the White Sox, Bieber is 5-2 with a 2.66 ERA.

Best Bets for this Game

Full-Game Side Bet

Insiders Status:


The Indians and White Sox have played each other dead-even this season, so I recommend looking for the value. There was no line posted as of late Thursday night, but I think the White Sox will come at a reasonable price seeing that Cleveland will be starting ace Shane Bieber, and the White Sox have clinched the division. Bieber is one of the best pitchers in baseball, but he has not pitched at the MLB level in over three months. In two minor league rehab starts, Bieber struggled by allowing four earned runs in six total innings.

I will take the White Sox, who have played well behind Dylan Cease on the road, to win this game.

Prediction: Chicago White Sox -113

Full-Game Total Pick

Insiders Status:


I don't expect to see the best from Shane Bieber in this game after he has struggled in both of his minor league rehab starts. On the other side, Dylan Cease has struggled in his career against the Indians with a 7.27 ERA in four starts. Seven of the last 10 head-to-head games between these teams have gone over the total, and I will take the over again here.

Prediction: Over

Written By David Marotta , "David Delano"

David Delano is a Bowling Green State University graduate with a passion for sports, traveling, and music. David loves to handicap MLB, NFL, NCAAF, NCAAB, NBA, WNBA, and is also a big fan of boxing and track and field. Over the years, David has worn several hats in the sports world, from being behind the camera to writing, filming, editing, scouting, and coaching, along with servicing his clients as a sports handicapper.  He is also an expert sports bettor. We are glad to have David on our Winners & Whiners team, and we recommend that you follow along with him every day.