In-Depth Prediction, Preview, and Odds
Cardinals vs. 49ers Prediction
Levi's Stadium, Santa Clara
Table of Contents
- Introduction & Team Review
- The Running Game
- The Passing Game
- Final Outlook & Prediction
- Second Opinion on this pick from StatSalt.com
- Latest Updates, Injury Reports, & Line Movements
- Insiders' Best Bets
Last Updated: Sunday, November 17, 2019 at 8:59am EST
It’s a battle of teams at opposite ends of the spectrum in the NFC West in the city by the bay. The Arizona Cardinals are on the road as they travel to face the San Francisco 49ers Sunday afternoon. Arizona was defeated 30-27 on the road by Tampa Bay in their previous game last Sunday. San Francisco suffered their first loss of the season last week, falling 27-24 in overtime to Seattle at home on Monday Night Football. The 49ers lead the all-time regular season series 30-26: their 28-25 win on October 31 on the road snapped Arizona’s eight-game win streak in the series.
Arizona Cardinals Review
Arizona started the season slowly, as you might expect with a rookie coach (Kliff Kingsbury) and a rookie quarterback (top overall pick Kyler Murray) manning key positions. The Cardinals used a fourth-quarter rally to open the season with a 27-27 tie at home against Detroit. Arizona then dropped three straight games as they fell to Baltimore (23-17) on the road followed by home losses to Carolina (38-20) and Seattle (27-10) before getting things going. The Cardinals bounced back with three straight wins as they edged Cincinnati 26-23 on the road on the final play of the game. Arizona then edged Atlanta 34-33 at home thanks to a missed extra point by Matt Bryant and held off the Giants 27-21 on the road to get back to the .500 mark. Since then, it’s been downhill as the Cardinals were drubbed (31-9) on the road by New Orleans and beaten (28-25) at home by the 49ers heading into last week against Tampa Bay.
The Cardinals had their opportunities but penalties, miscues and settling for field goals cost them dearly in a three-point loss. In the second half alone, the Cardinals turned the ball over on downs at the Tampa Bay 23, fumbled at the Buccaneers’ 11 and threw an interception on a play that began at the 15. Even if they had settled for field goals on those three drives, that’s nine points at minimum left on the field in a three-point loss. As it stood, the Arizona defense allowed the Tampa Bay offense to go 92 yards in six plays to score the winning touchdown with 1:43 to play immediately after that pick. The Cardinals were outgained 457-417, gave up 26 first downs while picking up 20 and was dominated in time of possession 36:03 to 23:57 in the game. Arizona did force three turnovers while committing two but failed to capitalize fully on them. The Cardinals mustered just three points off the Buccaneers miscues.
San Francisco 49ers Review
San Francisco is off to a strong start and looks nothing like the team that finished the 2018 season 4-12. The 49ers have as many wins after 10 weeks this season (eight) than they’ve had in any season in the last five years: their best mark in that span is an 8-8 mark in 2014. San Francisco started the year with a pair of road wins as they downed Tampa Bay 31-17 followed by a 41-17 dismantling of Cincinnati. The 49ers followed that with home wins over Pittsburgh (24-20) and, after a bye, Cleveland (31-3) to set up an NFC West showdown with the Rams. San Francisco completely shut down the Los Angeles offense, winning 20-7 on the road and holding Jared Goff to 78 passing yards. That was followed by a 9-0 road win over Washington in a game played in monsoon conditions before a 51-13 demolition of Carolina at home. San Francisco edged Arizona (28-25) on the road in week 9, setting up their Monday night clash with Seattle.
The 49ers started strong, jumping to a 10-0 lead after the first quarter, but found themselves down 21-10 in the fourth quarter. San Francisco’s defense created a spark when DeForest Buckner recovered a fumble and returned it for a score. The 49ers tied the game at 21 and then again at 24 on a Chase McLaughlin field goal with one second to play in regulation. In overtime, San Francisco had a chance to win after an interception but McLaughlin missed a 47-yard field goal attempt. After an exchange of punts, the Seahawks kicked the game-winning field goal as time expired to hand the 49ers their first loss of the year. San Francisco was outgained 336-302 and was edged in time of possession 35:19 to 34:41 in the game. The 49ers did own a 21-19 edge in first downs and forced four turnovers while committing three. Both teams scored on fumble returns in the contest.
The Running Game
Arizona Cardinals Running Offense
49ers Running Defense
Arizona Cardinals Running Offense
Arizona has been pretty effective moving the ball on the ground when they’ve been able to commit to it this season. The Cardinals have run for at least 100 yards in seven of their 10 games this season. Arizona has gone for more than 150 yards twice on the year, highlighted by a 266-yard showing against the Bengals in their week five victory. Seven times this season, the Cardinals have averaged better than four yards per carry. The team made a deal out of necessity right before the trade deadline last month, acquiring Kenyan Drake from Miami due to injury woes.
David Johnson is second on the Cardinals with 82 carries for 302 yards and two scores this season. He played only three snaps against the Giants in week seven and missed weeks eight and nine before returning against Tampa Bay. Chase Edmonds (58 carries, 295 yards, four TD) has been solid but has missed the last couple of weeks with a hamstring injury. Kyler Murray has run the ball 59 times for a team-high 351 yards and two scores this season from his quarterback spot. Drake has contributed 25 carries for 145 yards and a score in his two games with the team. As a team, the Cardinals have nine run plays of at least 20 yards this season: Edmonds and Murray each have four while Drake has one. Arizona has moved the chains 62 times via the ground game this season.
49ers Run Defense
San Francisco has had their struggles stopping the opposing ground game this season despite their success. The 49ers have given up more than 100 yards on the ground in seven or their nine games, including the last six straight contests. Four times in that six-game stretch, the opposition has picked up at least five yards a carry. Arizona gashed them for 153 yards two weeks ago in the first meeting while Seattle racked up 147 on Monday night. It’s clearly something that defensive coordinator Robert Saleh is going to have to address.
Fred Warner leads the team with 58 tackles (43 solo) plus two forced fumbles so far this season. Kwon Alexander (34 tackles, forced fumble), safety Jaquiski Tartt (38 tackles, forced fumble, fumble recovery), defensive end DeForest Buckner (39 tackles, two forced fumbles, three fumble recoveries, TD) and Richard Sherman (35 tackles) are among the team leaders in tackles this season. Nick Bosa (29 tackles, forced fumble, fumble recovery) leads the team with 12.5 tackles for loss while Arik Armstead (31 tackles, two forced fumbles, fumble recovery) contributes 9.5 and Ronald Blair III (21 tackles, fumble recovery) adds eight on the year. The 49ers have recorded 67 tackles for loss, 14 forced fumbles and nine fumble recoveries, with one scoop-six score, on the year as a team. Alexander hit injured reserve earlier this month with a torn pectoral, likely ending his season.
- 24th in run play percentage (37.46 percent)
- 22nd in rushing attempts per game (23.6)
- 14th in rushing yards per game (116)
- 5th in yards per carry (4.9)
- Tied for 13th in rushing TD (nine)
- 24th in longest rush (37 yards)
- 20th in percentage of run plays against (41.47 percent)
- 9th in run plays per game against (23.2)
- 18th in rushing yards allowed per game (107.8)
- 24th in opposing yards per carry (4.6)
- Tied for 3rd in rushing TD allowed (four)
- 8th in longest rush allowed (40 yards)
Who has the Edge?
The Cardinals have been decent with the run game even though they keep having to shuffle backs. Johnson was healthy last week but saw only five carries for two yards and had one reception for eight yards. After he fumbled, he was taken out of the game and Drake took over. San Francisco has been solid against the run but gave up 300 yards in their last two games. The 49ers have to show they can stop the run here in order to have success. Give Arizona a slight advantage here.
Advantage: Arizona Cardinals
49ers Running Offense
Arizona Cardinals Running Defense
49ers Running Offense
San Francisco has used a power run game to move the sticks, pile up points and grind the clock on opposing defenses. The 49ers have been extremely effective with the run game, rotating backs and pounding teams into oblivion. San Francisco started the season slowly, running the ball 32 times for 98 yards against Tampa Bay, but has battered the opposition since. The 49ers ran 42 times for 259 yards against Cincinnati in week two, 40 times for 168 yards against Pittsburgh in week 3 and thrashed the Browns for 40 carries for 275 yards on Monday Night Football in week five. San Francisco has run the ball for more than 100 yards six times this season and they haven’t racked up less than 87 yards in a game: that came last week against Seattle. The 49ers finished with 30 carries for 101 yards against Arizona in the first meeting.
Matt Breida leads the team with 109 carries for 542 yards plus a score this season as one of a three-headed committee for the 49ers. Raheem Mostert contributes 61 carries for 335 yards plus a score while Tevin Coleman has 92 carries for 395 yards and five touchdowns. Jeff Wilson Jr. (25 carries, 78 yards, four TD) proved to be a solid short yardage back while Coleman was out and provides depth in the backfield. The 49ers have nine run plays that have covered at least 20 yards this season: Breida and Coleman each have three. Mostert adds two while Deebo Samuel (five carries, 37 yards, TD) has one. San Francisco has moved the chains 70 times via the ground so far this season.
Arizona Cardinals Run Defense
Arizona has had serious deficiencies when it comes to stopping the run this season. The Cardinals have given up at least 100 yards in each of their 10 games this season and they’ve held just two teams under four yards per carry thus far. That is not the kind of numbers that you want to have when the 49ers are on the docket. To be fair, the Cardinals did a decent job against the run in the first meeting, limiting San Francisco to 3.3 yards per carry, which is the best yard per carry average the team has given up all season. The problem for Arizona will be repeating that performance in this contest.
Linebacker Jordan Hicks leads the Cardinals with 98 tackles (57 solo) along with two forced fumbles this season. Budda Baker (85 tackles, forced fumble, fumble recovery), Haason Reddick (67 tackles, fumble recovery) along with corners Byron Murphy Jr. (52 tackles) and Tramaine Brock Sr. (29 tackles) are making plays on the defensive side of the ball as well. Terrell Suggs (34 tackles, four forced fumbles) leads the team with 12 tackles for loss while Chandler Jones (27 tackles, five forced fumbles, three fumble recoveries) contributes 11 and Hicks has eight on the year. The Cardinals have amassed 69 tackles for loss, forced 13 fumbles and recovered six as a team this season.
- 1st in run play percentage (53.23 percent)
- 1st in rushing attempts per game (36.7)
- 2nd in rushing yards per game (161.8)
- 11th in yards per carry (4.4)
- Tied for 3rd in rushing TD (13)
- 4th in longest rush (83 yards)
- 19th in percentage of run plays against (41.09 percent)
- 25th in run plays per game against (27.9)
- 24th in rushing yards allowed per game (126)
- 20th in opposing yards per carry (4.5)
- Tied for 7th in rushing TD allowed (six)
- 27th in longest rush allowed (76 yards)
Who has the Edge?
San Francisco's run game has been a battering ram this season and they will continue to pound the rock to make life miserable for opposing defenses. The 49ers have a trio of backs that can contribute on any given day and make life tough, especially since they can be rotated in and out. Arizona has been inconsistent against the run game and they have their work cut for them here. The Cardinals got the better of San Francisco in this department the first time but the script flips here.
Advantage: San Francisco 49ers
The Passing Game
Arizona Cardinals Passing Offense
vs. 49ers Passing Defense
Arizona Cardinals Passing Offense
Arizona has had to go to the air more than they would like to with a rookie quarterback this season. The Cardinals have thrown at least 32 passes in seven of their eight games this season. Arizona has managed to taper down slightly as they threw at least 40 passes in each of their first three games but hasn’t gone over 37 in six straight games before tossing 45 against Tampa Bay in the loss last week. The Cardinals have four 300-yard games through the air this season, including a season-high 350 yards against the Buccaneers last week. Against San Francisco in the first meeting, Arizona threw for 241 yards and a pair of scores.
Kyler Murray is 230 of 360 passing on the season for 2,553 yards with 12 touchdowns and five interceptions on the season. He has been sacked 31 times for a loss of 218 yards this season. Brett Hundley misfired on his lone pass attempt, though he has been sacked once for a loss of four yards. Punter Andy Lee completed his lone pass attempt for 26 yards. Larry Fitzgerald leads the team with 50 receptions for 556 yards and two scores this season. Christian Kirk contributes 40 receptions for 467 yards and three scores while Johnson (31 catches, 323 yards, three TD), Damiere Byrd (17 grabs, 178 yards) and KeeSean Johnson (19 receptions, 173 yards, TD) are making plays in the passing game. The Cardinals have 27 pass plays that have covered at least 20 yards on the season with Fitzgerald leading the way with eight: David Johnson has six while Kirk adds five.
49ers Passing Defense
San Francisco’s pass defense has gotten a fair amount of work, mainly because they’ve built up comfortable leads that have forced the opposition to the air. The 49ers have been solid against the pass, giving up just one 300 yard passing game this season. San Francisco has held their last seven opponents to 241 yards or less through the air. That includes a five-game stretch where they didn’t allow more than 174 yards passing from weeks 3 through eight (the team was off in week 4): they allowed less than 100 net passing yards in three straight games and a fourth right at the 100-yard mark. Arizona got 241 yards two weeks ago while Seattle had 232 on Monday night, though 189 net yards after the sacks were factored in.
Bosa and Armstead share the team lead in sacks with seven apiece on the year. Dee Ford (12 tackles, 5.5 tackles for loss, two forced fumbles, pass defense) adds 5.5 sacks this season while Buckner contributes four. Richard Sherman leads the team with nine pass defenses while Ahkello Witherspoon (nine tackles, tackle for loss) and Emmanuel Moseley (24 tackles) each have five on the year. Sherman (TD) leads the team with three interceptions on the year while K’Waun Williams (31 tackles, sack, two tackles for loss, two forced fumbles, two pass defenses) has two. Alexander, Mark Nzeocha (five tackles, pass defense), Bosa, Moseley, Dre Greenlaw (27 tackles, sack, tackle for loss, pass defense) and Witherspoon (TD) each have one interception this season. As a team, San Francisco has picked up 35 sacks, 45 pass defenses and 11 interceptions with two picks returned for scores this season.
- 9th in pass play percentage (62.54 percent)
- 19th in completion percentage (63.8)
- 16th in passing yards per game (235.7)
- Tied for 21st in TD passes (12)
- Tied for 7th in INT thrown (five)
- 19th in net yards per pass attempt (6.5)
- 3rd in longest pass play (88 yards)
- 19th in passer rating (90.2)
- 13th in pass play percentage faced (58.53 percent)
- 1st in passing yards per game allowed (143.8)
- 2nd in completion percentage allowed (58.1)
- 4th in TD passes allowed (five)
- 4th in INT (11)
- 2nd in sacks (35)
- 2nd in passer rating allowed (68.5)
- 2nd in net yards per pass attempt (five)
Who has the Edge?
Arizona has been decent moving the ball through the air as Murray has dodged a lot of the mistakes that befall rookie quarterbacks on a regular basis. The problem for the Cardinals is that they have a shaky offensive line and a slew of young receivers. San Francisco has been terrific against the pass this season. The 49ers get terrific pressure against opposing quarterbacks and they are getting turnovers, which is something they lacked last season. Look for San Francisco to have the advantage here.
Advantage: San Francisco 49ers
49ers Passing Offense
Arizona Cardinals Passing Defense
49ers Passing Offense
San Francisco hasn’t had to rely on the passing game as much this season as the run game has done the job beating teams into submission. The 49ers have thrown for more than 300 yards just twice in a game this season. San Francisco racked up 312 yards in a blowout win against the Bengals back in week two. Their other 300-yard game came against these same Cardinals as they went for a season-high 317 yards plus four scores through the air. Last week against Seattle, the 49ers finished with 248 yards passing though they were sacked five times in the contest.
Jimmy Garoppolo has hit 184 of 272 passes for 2,054 yards with 14 touchdown passes against eight interceptions on the year. He has been sacked 17 times this season, losing 102 yards in the process. Dante Pettis completed his lone pass attempt for 16 yards this season. Tight end George Kittle has reeled in a team-leading 46 passes for 571 yards and two scores this season. Deebo Samuel (30 receptions, 339 yards, TD) and Marquise Goodwin (11 grabs, 181 yards, TD) are the next most reliable options in the passing game. The 49ers acquired Emmanuel Sanders (13 catches, 161 yards, two TD in three games with the team) from Denver prior to their week 8 contest against the Panthers, adding a proven veteran receiver to the mix. San Francisco has 29 plays that have covered at least 20 yards: Kittle leads the team with seven while Samuel adds five: Goodwin, Sanders and Kendrick Bourne (15 receptions, 200 yards, two TD) each have three.
Arizona Cardinals Passing Defense
Arizona has been inconsistent in pass defense this season, though a fair amount of that can be attributed to the fact that Patrick Peterson missed the first six games after violating the league’s substance-abuse policy. The Cardinals have given up more than 300 yards five times this season. Arizona has been pretty effective getting after the quarterback, recording at least one sack in nine of their 10 games. The Cardinals have been terrible in coverage of late though as they have given up more than 300 yards through the air in four of their last five games after doing that just once in their first five contests.
Jones (two pass defenses) leads the team with 11.5 sacks on the season while Suggs has 5.5 of his own. Corey Peters (24 tackles, 4.5 tackles for loss) adds 2.5 sacks while Rodney Gunter (24 tackles, 6.5 tackles for loss) adds two. Baker and Murphy Jr. each have six pass defenses to share the team lead. Hicks and Reddick are right behind them with five apiece. Hicks leads the team with two picks on the year. Patrick Peterson (19 tackles, sack, tackle for loss, forced fumble, pass defense) and Murphy Jr. each have recorded an interception on the season. Arizona has picked up 27 sacks as a team this season while recording 33 pass defenses and four interceptions.
- 32nd in pass play percentage (46.77 percent)
- 8th in completion percentage (67.8)
- 22nd in passing yards per game (218.7)
- Tied for 16th in TD passes (14)
- Tied for 20th in INT thrown (eight)
- 11th in net yards per pass attempt (7.2)
- Tied for 31st in longest pass play (45 yards)
- 13th in passer rating (95)
- 14th in pass play percentage faced (58.91 percent)
- 31st in passing yards per game allowed (286.5)
- 30th in completion percentage allowed (70.5)
- 32nd in TD passes allowed (25)
- Tied for 26th in INT (four)
- Tied for 8th in sacks (27)
- 31st in passer rating allowed (112.8)
- 27th in net yards per pass attempt (7.7)
Who has the Edge?
The Cardinals have been gashed by the pass repeatedly this season. Even San Francisco went for over 300 yards against the Arizona defense in the first meeting. The Cardinals are prone to giving up big plays and they tend to get lit up by opposing tight ends. San Francisco doesn't throw a ton but when they have an opportunity to exploit things, they take advantage. Garoppolo was sharp against Arizona in the first meeting: he does the job again here.
Advantage: San Francisco 49ers
Arizona enters week 11 17th in the league in scoring offense as they put up 22.2 points per game this season. The Cardinals are 18th in the league in total offense with 351.7 yards per contest and stand 16th in yards per play with an average of 5.6 yards a snap. Arizona is 27th in scoring defense as they allow 28.1 points per game. On the season, the team is 31st in total defense by allowing 412.5 yards per game and 29th in yards per play allowed as they give up 6.1 yards per play on average. Arizona is tied for 8th in the league in giveaway/takeaway with a +4 margin this season.
The Cardinals are second to last in the league in scoring touchdowns in the red zone as they cash in a measly 34.29 percent of their chances. Defensively, Arizona is below average as they are 24th in red zone defense by allowing 60.53 percent of drives to reach the red zone to end in touchdowns. The Cardinals are slightly below average in third down conversions, ranking 20th by converting 36.92 percent of their third-down situations. Arizona’s defense is struggling, ranking 30th in those situations as they hold the opposition to a 46.56 percent success on their third downs. The Cardinals are 31st in the league in time of possession by holding the ball 44.25 percent of the time this season.
Zane Gonzalez has hit all 18 extra point attempts and 24 of 27 field goal tries this season with a long of 54. Andy Lee has punted the ball 36 times for a 48.6-yard average (42.2-yard net average) this season. He has dropped 11 punts inside the opponent’s 20-yard line with three touchbacks: he has had one punt blocked. Ryan Winslow averaged 48.5 yards (44.5 net) on six punts filling in for Lee while Gonzalez had a 42-yard average on two punts. Pharoh Cooper averages 23.7 yards on 10 kick returns with a long of 39 while Andy Isabella averages 21 yards on five returns with a long of 32. Cooper has averaged 6.3 yards on nine punt returns with a long of 17 while Kirk averages 5.6 yards on seven returns with a long of 20 this season.
San Francisco enters this contest 4th in the league in scoring offense as they put up 28.8 points per game this season. The 49ers are 9th in the league in total offense with 380.4 yards per contest and stand 18th in yards per play with an average of 5.5 yards a snap. San Francisco is 2nd in scoring defense as they allow 14.3 points per game. On the season, the team is 2nd in total defense by allowing 251.6 yards per game and 2nd in yards per play allowed as they give up 4.5 yards per play on average. San Francisco is tied for 5th in the league in giveaway/takeaway with a +5 margin this season.
The 49ers are only 23rd in the league in scoring touchdowns in the red zone as they cash in 48.57 percent of their chances. Defensively, San Francisco is sharp as they are 1st in the league in red zone defense by allowing a measly 36.84 percent of drives to reach the red zone to end in touchdowns. The 49ers are above average in third down conversions, ranking 5th by converting 47.58 percent of their third-down situations. San Francisco’s defense is solid in those situations, ranking 2nd as they hold the opposition to a 30.19 percent success on their third downs. The 49ers are 2nd in the league in time of possession by holding the ball 57.54 percent of the time this season.
Robbie Gould has hit all 26 extra point attempts but is just 13 of 20 on field goal attempts with a long of 47 this season. Chase McLaughlin hit his lone extra point and is three of four on field goals with a long of 47. Mitch Wishnowsky has averaged 44.3 yards per punt (41.5-yard net average) on 30 punts this season. He has dropped 14 punts inside the opposing 20-yard line with only two touchbacks on the year. Richie James Jr. has averaged 17.5 yards per kick return on 10 runbacks: he has averaged 9.3 yards per punt return on 25 chances this season with a long of 32.
Who has the Edge?
San Francisco has been excellent this season and it remains to be seen if things can continue that way. The 49ers are terrific defensively and they've been efficient offensively as well. Arizona has done their part on offense but their defense has had serious issues when it comes to making plays. Both teams have positive numbers in the takeaway/giveaway ratio, which is something to build around. The kicking game is solid for the Cardinals but most other statistics lean San Francisco's way. Give the 49ers the edge.
Advantage: San Francisco 49ers
San Francisco won the first meeting two weeks ago in the desert by three, though the Cardinals had a long TD pass in the final three minutes to make it a one-score game. The 49ers are a tough team right now and the Cardinals have their work cut out for them on the road. San Francisco is 3-1 at home on the season while Arizona is 2-3 on the road. The Cardinals are struggling to stop opposing teams and it's hard to see them suddenly turning things around here. Arizona hangs around for a while but San Francisco turns it on and buries them in the second half.
According to Covers.com, the 49ers are 5-2 ATS in their last 7 games after accumulating less than 90 yards rushing in their previous game. Arizona is 3-8 ATS in their last 11 games after accumulating more than 250 yards passing in their previous game and 0-4 ATS in their last 4 games in Week 11.
Latest Updates, Injury Reports, and Line Movements
Chase Edmonds remains out with a hamstring injury, which means Kenyan Drake and David Johnson will see the bulk of the work in the run game. Tackle Justin Murray is questionable with a knee injury: Justin Pugh would step in to take his spot. Defensively, Jonathan Bullard is out with a foot injury at the defensive end spot, putting Michael Dogbe in the mix. Backup defensive tackle Zach Kerr is questionable, as is starting linebacker Terrell Suggs. If Suggs can't go, then Cassius Marsh Sr. would step up.
San Francisco has a lot of injuries on their report. Tackle Joe Staley is out after thumb surgery this week: that pushes Justin Skule back in the mix. Tight end George Kittle (knee) and running back Matt Breida (ankle) are doubtful. That means Ross Dwelley and Garrett Celek are going to have to step up and contribute at tight end, while Coleman, Mostert and Wilson Jr. will see more reps at running back. Kicker Robbie Gould is doubtful as well, which means McLaughlin gets another week to kick. Mostert is questionable as is Emmanuel Sanders, who says he will try to play through a rib injury. Dante Pettis is also questionable with a groin injury.
The weather should be just about perfect for mid-November football. The game-time temperature is expected to be in the low-70s for this contest with clear skies. Winds are expected to come from the north-northwest around five miles an hour with gusts up to 10 miles per hour. There is no precipitation in the forecast for the tailgaters. When you get right down to it, you can't complain all that much about weather like this for football in week 11.
When the initial lines opened for this contest, San Francisco was installed as a 14-point favorite with the over/under set at 44 points. As of Saturday afternoon, the line has moved downward somewhat with the 49ers are now a 10-point favorite in the contest. The over/under has stayed flat at 44 points in this contest. Currently, the moneyline shows San Francisco a lofty -500 to -550 favorite while the Cardinals can be found as a +350 to +400 underdog depending on the sportsbook. As of this writing, 73 percent of the bets are backing the Cardinals +10 points. When it comes to the moneyline, a solid majority, 91 percent of the wagers, are backing the Cardinals as the visiting team. Meanwhile, 51 percent of bets are projecting this one to stay under the total.
There are a slew of injuries for the 49ers as they come in off their first loss of the season. With that said, San Francisco is still the better team as the Cardinals have plenty of youth that is still adjusting to the NFL level. We saw the 49ers beat the Cardinals on the road two weeks ago: they should be able to take care of business at home here as well.
Prediction: San Francisco 49ers -10.5Second Opinion on this pick from StatSalt.com
Additional Insiders' Best Bets
Full-game Total Bet
These teams combined for 53 points in the first meeting this season though that came in a favorable climate setup since the Cardinals have a retractable roof. This one could be a little different depending on how the weather is. San Francisco has seen the over go 2-2 in their four home games this season while the Cardinals have seen the over go 2-3 in their road games on the year. Arizona has had their problems defensively and they face a challenge here on the road against a tough San Francisco team. Can Arizona find a way to step up on the defensive side of the ball?
The under is 7-3 in the Cardinals' last 10 games after accumulating more than 250 yards passing in their previous game. San Francisco has seen the under go 6-2 in their last eight after a straight up loss and 5-2 in their last seven in week 11. This one has the makings of a 28-14 or 28-16 type of game here that ends up falling short of the mark. If the weather kicks up, things likely could trend further down.
Half-time Side Bet
San Francisco has been solid in the first half of games as they make life extremely difficult for opposing teams to put points on the board. We've seen that Arizona struggles to put points up early in games and that's going to be an issue for them here. The 49ers are at home and they are the better team on paper. It's hard to see the Cardinals doing a ton offensively in the first half. After all, they had their struggles in the first half in the meeting two weeks ago. San Francisco is up at the half here.
Half-time Total Bet
San Francisco is 10th in the league in first-half scoring with 13.2 points per game in their games this season. Arizona comes in 20th in that category with 9.8 points per game in the first half of their contests. The 49ers are stout defensively in first half scoring defense, ranking second in the league by allowing 5.6 points per game. Arizona is just 28th in that category as they allow 14.6 points in the opening half of games this year. Look for this one to be 14-3 or 17-3 at the half. That leaves this one under the number.