Sunday Night Football features a high profile matchup between the San Francisco 49ers (5-6) and the Buffalo Bills (9-2). These teams have not played since 2020 when the Bills won by ten. San Francisco took a harsh loss in Green Bay last week, going down 38-10 as 6.5-point road underdogs. The Bills had a bye last week, and defeated the Chiefs in the previous week 31-20 as 2.5-point home favorites. The Bills are currently listed as 7-point home favorites in this matchup. Kickoff is scheduled for 8:20 EST from High Mark Stadium in Orchard Park, and can be found on NBC.
Need quality winners? This is the ultimate site for NFL Picks.
Who wins this prime time matchup? Read on to see our49ers vs. Bills prediction.
San Francisco in Last
The San Francisco 49ers find themselves in an unfamiliar spot, sitting in last in the NFC West. There is still plenty of time to climb the standings, as the Rams and Seahawks have 6-5 records, and the Cardinals and 49ers are at 5-6. San Francisco has lost their last two games coming into this one, they dropped a home game to the Seahawks, then got rolled by the Packers. In the loss against Green Bay, backup quarterback Brandon Allen got the start and finished with 199 yards with one TD and one INT in the game.
Head coach Kyle Shanahan was not pleased with the team's performance against the Packers, he spoke to reporters after the game saying, “I thought we had way too many missed tackles. Just them being able to control that clock the first half was one of the worst ones I’ve been a part of as far as a half.”
Brock Purdy is questionable for this game after sitting out against Green Bay. Purdy has a shoulder injury, and if he cannot go, Brandon Allen will get another start. Christian McCaffrey has played in just three games and has not looked like his former self. He has 149 yards through the three games, with a high of 79 against Seattle. Jordan Mason is likely to continue to get carries, he has 711 yards and three touchdowns on the year. George Kittle has been their top pass catcher, he has 49 catches for 642 yards and eight touchdowns.
San Francisco ranks 13th in the NFL in scoring with 23.6 points per game, and their defense ranks 21st by giving up 23.6 per game. Fred Warner has been their top tackler from the linebacker spot with 84 on the year and has two of the team's 11 interceptions. Deommodore Lenoir has two interceptions as a corner, but is listed as questionable for this game. Nick Bosa is also listed as questionable, while would leave defensive end Leonard Floyd as their sack leader with 6.5 of the team's 28 on the season.
Injury Report:
Questionable: QB Brock Purdy, WR Chris Conley, T Trent Williams, DE Nick Bosa, DT Kevin Givens, CB Deommodore Lenoir,
Need assistance with pro football? We have the Best NFL Cappers!
Bills Win Six Straight
The Buffalo Bills have won their last six games, and continue to dominate their division as they currently have a four-game lead over the second-place Dolphins. The Bills have only lost two games all season, both coming on the road against the Ravens and Texans. Buffalo is 5-0 at home, and will now host a 49er team that is desperate for a win after falling into 4th in the NFC West. In their last game, the Bills took down Patrick Mahomes and the Chiefs behind 262 passing yards and a touchdown from Josh Allen.
Allen had a 26-yard touchdown run to seal the win over Kansas City, leading receiver Khalil Shakir to say, “When Josh takes off, I find myself just watching, like, ‘Wow, he’s different. When he took off today, I just started yelling. I couldn’t stop yelling. I was blanking in the head.” Josh Allen is still fighting for his first MVP trophy and has his name in the running again with 2,543 passing yards on a 64.0% completion rate with an 18-5 TD-INT ratio. Allen is second on the team in rushing with 316 yards and another five scores. James Cook is their top back, he has 596 yards on 4.3 YPC with 10 touchdowns. Khalil Shakir has been their top pass catcher, he is a 6'0 receiver with 56 catches for 599 yards and two touchdowns.
The Bills are 3rd in the NFL in scoring with 29.1 points per game, and their defense ranks 7th by giving up just 19.5 points per game. Linebacker Dorian Williams leads the team in tackles with 97, over thirty more tackles than the next highest Bill. They have 27 sacks on the year, led by edge rusher Greg Rosseau with 5.5. They have 13 interceptions on the season with six players contributing two each including safety Damar Hamlin.
Injury Report:
Questionable: WR Keon Coleman, TE Dalton Kincaid
Check out some of the most amazing sports betting opportunities and Sportsbook promo codes.
Craig Trapp - Smoking HOT 8-1 Best Bet Run Last 5 Days - 6 Winners Today - 2 Week Pass Just $99 - CLICK HERE
David Hess - 17-5 NFL Primetime Sides - Grab David's Sunday Night Football Bookie BusterFor Just $30 - CLICK HERE
AAA Sports - 23-7 NFL Run - Grab Their Sunday NFL Earliest Cash for just $50 - CLICK HERE
Marc David - 14-3 NFL Run - Pick Up Marc's Non-Conference NFL Game Of The Month for just $50 - CLICK HERE
Nick Parsons - 14-5 NFL Run - Grab Nick's Sunday Night Football Totals Bloodbath for just $35 - CLICK HERE
Best Bets for San Francisco 49ers vs. Buffalo Bills
Full-Game Side Bet
Insiders Status:
The Buffalo Bills have been dominant over the past several weeks, and there is no reason to think they will slow down here. The injuries have been too much for the 49ers to handle here. They were without Christian McCaffery for the beginning of the season, but now he is back just in time for Brock Purdy, Nick Bosa and Trent Williams to all be on the injury list. Speaking of McCaffery, he has not looked like the former All-Pro player, as he has not rushed for over 100 yards yet on the season. McCaffery was a touchdown machine, but has now not scored in any of his three games. Brandon Allen did not show anything last week to give us confidence here, they only scored 10 points all game against the Packers. Nick Bosa is an elite edge rusher, and Trent Williams might be the best non-quarterback in the NFL. The Bills will be able to get pressure on Allen or Purdy, especially if Williams is out or limited. The Bills have won all of their last five games by at least a touchdown and will cover here in prime time.
Take the Bills to cover.
Full-Game Total Pick
Insiders Status:
The Buffalo offense is rolling, and will continue here against the 49ers. San Francisco has a reputation of being a strong defense, but the numbers do not back it up, they rank 21st in the league in points allowed. They will be going up the Buffalo offense that has always been strong with Josh Allen, but the addition of James Cook has given this offense a new dimension. Cook has punched the ball in the endzone 10 times, giving the Bills a reliable running game that they have not had in the past few years. The Bills have scored at least 30 points in each of their last five games, and will put up numbers on a San Fran defense that could be without their best pass rusher if Bosa is out. Coach Shanahan has had time to assess which players will be available, and cook up schemes to try to manufacture scoring drives. They only scored 10 points last week, but Shanahan is too good of an offensive mind to let that happen again. The Bills have gone over in their last three games, and will go over again here.
Take the over.
