Prediction, Preview, and Odds
#281 San Francisco 49ers vs.
#282 Philadelphia Eagles
Sunday, September 19, 2021 at 1:00pm EDT
Lincoln Financial Field, Philadelphia
Written by Nick Raffoul

The San Francisco 49ers will travel to Lincoln Financial Field on Sunday afternoon for a Week 2 battle against the up-and-coming Philadelphia Eagles.

Despite leading by as many as 28 points, San Francisco barely escaped with a Week 1 win on the road against the lowly Detroit Lions. Meanwhile, Philadelphia turned heads with a dominant performance on the road against the Atlanta Falcons

Can Philadelphia keep its momentum going with an upset win at home against the 49ers in Week 2 on Sunday?

Line Movements & Weather

The 49ers have gone from -4 down to -3, despite the fact that they have snatched up 61% of the bets for the week. The Sharps are all over the Eagles.

The OU line has gone from 45.5 up to 49 at most shops with the Over grabbing 67% of the bets.

Gametime Weather: Sunny skies with temps in the upper 70s.

49ers beat Detroit, lose Mostert to injury in Week 1

The 49ers took down the Detroit Lions 41-33 at Ford Field last weekend. Trey Lance threw San Francisco’s first touchdown of the season, a five-yard strike to Trent Sherfield in the first quarter, and sixth-round rookie Elijah Mitchell rushed for 104 yards and a touchdown in the win. The 49ers led 38-10 following Deebo Samuel’s 79-yard touchdown catch but took their foot off the proverbial gas pedal after that. Detroit scored 21 of the game’s final 28 points, converted on back-to-back 2-point conversions, and converted an onside kick to give the 49ers a legitimate scare late in the game.

San Francisco also got some bad news following the win. Starting running back Raheem Mostert left the game with a season-ending injury after just two carries, leaving the 49ers seemingly thin at running back. Mitchell, a sixth-round rookie, is expected to get the first crack at replacing Mostert after his Week 1 performance. JaMycal Hasty and Trey Sermon also figure to be working into the equation while running back Jeff Wilson Jr. works his way back from the PUP list as well. Head coach Kyle Shanahan will also have a chance to get creative with Lance, who could be a centerpiece in the 49ers rushing attack

On defense, San Francisco is fresh off of allowing 33 points and 454 yards of total offense against the Lions. The 49ers will have to find a way to overcome the loss of linebacker Dre Greenlaw, who is expected to miss four to six weeks after undergoing groin surgery, according to The Athletic.

Injury Report

Out - LB Dre Greenlaw, WR Jeff Wilson Jr., DB Jason Verrett, RB Raheem Mostert, WR Jalen Hurd, WR Richie James, DB Davontae Harris, DL Maurice Hurst, and DB Tarvarius Moore

Doubtful - DB Emmanuel Moseley

Questionable - LB Marcell Harris, DL Arik Armstead, and DT Javon Kinlaw

Hurts has breakout game to give Sirianni his first NFL win

Philadelphia throttled the Atlanta Falcons 34-6 in Week 1 behind a breakout performance from quarterback Jalen Hurts. Hurts completed 27 of 35 passes for 264 yards with three touchdowns and scrambled for 62 yards to help lead the Eagles to a commanding victory. Rookie wide receiver DeVonta Smith led the team with six catches for 71 yards and a touchdown while the defense limited Atlanta to just two first-half field goals in the win.

The Nick Sirianni era in Philadelphia is off to a strong start. Hurts looked poised and efficient in the pocket on Sunday, completing 77 percent of his passes while adding 62 yards on the ground. He executed run-pass options with ease and showed it by throwing for three touchdowns for just the second time in his NFL career.

Another Eagles’ rookie, fifth-round pick Kenneth Gainwell, also played an important role for Philadelphia in the season opener. Gainwell scored his first touchdown and appears to be the No. 2 running back after notching nine carries for 37 yards against Atlanta.

On defense, Philadelphia is fresh off of a strong effort against the Falcons. The Eagles allowed just six points and 288 yards of total offense, including 164 passing yards in the win against Atlanta.

Injury Report

Out - DB Rodney McLeod, DB Josiah Scott, OT Jack Driscoll, and TE Tyree Jackson

Questionable - DE Ryan Kerrigan, and OT Andre Dillard

Best Bets for this Game

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Full-Game Side Bet

Insiders Status:


The 49ers come into this game favored by three points but recent history suggests that there could be some value on the Eagles in this spot. Since 2001, these two teams have met 12 times with Philadelphia emerging victorious in eight of those games. San Francisco looked sloppy in last week’s win versus Detroit and failed to close out what should have been a blowout win. The loss of Dre Greenlaw also hurts San Francisco’s defense, which gave up 21 points after halftime last week. The Eagles come into this game with some momentum on offense and Hurts showed some maturity under center, which bodes well for Philadelphia’s chances in this game. Take the Eagles to cover the spread at home in this Week 2 matchup on Sunday.

Prediction: Philadelphia Eagles +3

Full-Game Total Pick

Insiders Status:


These two teams are projected for 49.5 points but that mark seems a bit too high here. While the 49ers benefited from a few big plays against the Lions, the Eagles’ defense figures to present a much tougher challenge this week. Philadelphia allowed just six points and 260 yards of total offense against the Falcons last week. San Francisco also figures to put together a better performance than it did in the second half of last week’s win, so points could come at a premium for both teams in this one. Take this matchup to stay under the projected total at Lincoln Financial Field on Sunday.

Prediction: Under 49.5

Written By Nick Raffoul , "Nick Raffoul"

Shortly after graduating with an Honors in Business Administration, Nick turned his attention from traditional stocks and bonds to investing in the performance of sports teams. He has been a very successful sports bettor over the years and has now brought his talents to us here at Winners & Whiners. Nick uses a combination of advanced stats and historical data to create sports investment models to identify value and generate consistent profits. Let Nick win for you.