Prediction, Preview, and Odds
#485 Los Angeles Rams vs.
#486 Arizona Cardinals
Sunday, September 25, 2022 at 4:25pm EDT
University of Phoenix Stadium, Glendale
Written by The Admiral

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Los Angeles Rams (1-1) vs. Arizona Cardinals (1-1)

Week 3 of the 2022 NFL season brings an NFC West showdown from State Farm Stadium in Glendale, Arizona, where the Cards host the reigning Super Bowl champions. Here's the best Cardinals vs. Rams betting pick along with the latest odds update.   

It’s a rematch of the 2021 NFC wild-card round, and the Rams are listed as 3.5-point road favorites. The Cardinals are +155 moneyline underdogs with a total of 48.5 points.  

The Rams narrowly outlasted Atlanta for their first W of the season

After getting humiliated by the Buffalo Bills in their season opener, the Los Angeles Rams beat the Atlanta Falcons 31-27 in Week 2. The reigning champs failed to cover a ten-point spread, surrendering 17 points in the fourth quarter while scoring just three in return. Los Angeles had a 28-3 lead early in the third quarter, but the Falcons trailed by just six points with 4:57 left on the clock in the fourth. 

"There's a lot of different, very uncharacteristic things, but they happened. And we still found a way," Rams head coach Sean McVay said. "We're not going to run away from some of the things that we didn't do well today. But we're also going to allow ourselves to appreciate being able to come away with a win." 

The Rams outgained the Falcons 337-261 in total yards but ran for just 65 yards on 26 totes (2.5 yards per carry). Matthew Stafford went 27-of-36 for 272 yards, three touchdowns, and a couple of interceptions, while Cooper Kupp had 11 receptions for 108 yards and a couple of scores. 

Stafford now has five interceptions on the season, and the Rams need more from their starting quarterback. Stafford didn’t appear in the preseason and will need some time to build up his form. Last year, he had four interceptions through the first six weeks, finishing the season with a 41/17 TD/Int ratio.  

The Cardinals overcame a huge deficit in Week 2

The Arizona Cardinals started the 2022 season with a heavy 44-21 loss to the Kansas City Chiefs. They bounced back last Sunday, erasing a 20-point deficit at halftime to grab a 29-23 overtime victory at the Las Vegas Raiders. After going scoreless through the first 30 minutes, the Cards stunned the Raiders in the second half, as Byron Murphy Jr. returned a fumble for 59 yards with 3:51 left on the clock in overtime to lift Arizona over Las Vegas. 

"I think collectively we've just got to start faster," Cardinals head coach Kliff Kingsbury said. “I've got to do a better job of getting our offense off to a quicker start, there's no doubt. But we've seen Kyler Murray do that before, and he can make it go when he wants to." 

Kyler Murray was unstoppable in the second half, scrambling and making plays for Zach Ertz, Marquise Brown, and Greg Dortch. Murray finished with five carries for 28 yards, a TD, and a two-point conversion while going 31-of-49 for 277 yards, a touchdown, and an interception through the air. Arizona ran 28 times for 143 yards (5.1 per carry), and Darrel Williams led the way with eight totes for 59 yards and a TD in his first game as a Cardinal. 

Back in Week 1, Murray tossed for 193 yards and a pair of touchdowns. The Cardinals were awful on both sides of the ball through the first three quarters, allowing 37 points to the Chiefs and scoring just seven in a return.

Best Bets for this Game

Full-Game Side Bet

Insiders Status:


Both the Rams and Cardinals have been inconsistent so far this season, showing a lot of problems in their game. They also enter Week 3 with plenty of injury problems, so I’m expecting to see a tight battle down the stretch. The Rams are without cornerback Troy Hill and guard Tremayne Anchrum Jr., while fellow CB Cobie Durant and David Long are questionable to play against the Cardinals, who could miss RB James Conner. DeAndre Hopkins is suspended for the first six games of the season, which is a huge blow for Arizona’s offense. 

Sean McVay knows how to contain Kyler Murray and the Cardinals’ offense, so I’m going with the Rams. Since 2019 when Murray joined the NFL, the Rams have gone 6-1 straight up and 5-1-1 ATS against Arizona including a 34-11 victory in the 2021 wild-card showdown. Also, the Cardinals are yielding 7.6 yards per pass in 2022 (31st in the NFL) which is excellent news for Matthew Stafford and Cooper Kupp.

Prediction: Los Angeles Rams -3.5 (-110)

Full-Game Total Pick

Insiders Status:


The Rams had a tough season opener against the mighty Buffalo Bills, but surrendering 17 fourth-quarter points to Marcus Mariota and the Atlanta Falcons was a big surprise. On the other side, the Cardinals’ D stepped up in the second half in Vegas after a horrible first-half performance and an abysmal Week 1 against Kansas City. 

The over is 4-2 in the last six meetings between the Rams and Cardinals. Both teams have enough offensive firepower to surpass a 20-point mark and that should continue with a shaky defensive performance by both teams early in the season, so give me the over on the totals. 

Prediction: Over 48.5 points (-110)

Written By Admir Aljic , "The Admiral"

You want someone to show you how to make some money, then talk to the Admiral, because he is your man. He has been handicapping for many years, so heal knows a thing or two on how to beat the spread and get your pockets loaded with cash. He has lined his own pockets for years as a betting expert. The Admiral has brought his talents to StatSalt & Winners & Whiners and will always find the best pick for you.