Prediction, Preview, and Odds
#487 San Francisco 49ers vs.
#488 Denver Broncos
Sunday, September 25, 2022 at 8:20pm EDT
Sports Authority Field, Denver
Written by Mason Folz

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This Sunday night, the (1-1) San Francisco 49ers and the (1-1) Denver Broncos will match up in the third week of the 2022 NFL season. Kick-off will be at 8:20 PM EST inside Empower Field at Mile High. Both of these teams have had an interesting start to their season, as they are both (1-1) and dealing with a ton of injuries.

The San Francisco 49ers are coming into this one after taking down the Seattle Seahawks, 27-7. They did lose their starting quarterback Trey Lance for the season, as he suffered an ankle injury. The 49ers will now be starting Jimmy Garoppolo in this one.

The Denver Broncos picked up their first win of the season last week against the Houston Texans. They won 19-9 as they also lost some key players to injury. Jerry Jeudy is listed as questionable for this one, as he got banged up in week 2. They will need to get multiple players back if they want to have a shot on Sunday Night!

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Can the 49ers Make it Two in a Row?

The 49ers are currently scoring 18.5 points per game and averaging 352 total yards of offense. This is the 19th most points scored per game and the 15th most yards. The San Francisco 49ers lost Trey Lance for the season last week, as he went down with an ankle injury. They will now be starting Jimmy Garoppolo at quarterback. Last week he entered the game and finished with 154 passing yards, 1 touchdown, and a 60.4 QB rating. He looked solid, but the 49ers will still be looking to lean on the run. They are averaging 182.5 rushing yards per game, which is the fourth most in the league. They will continue to feed Jeff Wilson. He finished with 84 yards against the Seahawks, as he continued to pound the rock. San Francisco is also averaging 169.5 passing yards per game, as this is the second least. They haven't relied on their passing game much this season, but now that Garoppolo is starting, I would expect to see the ball in the air more. I would also watch for Deebo Samuel, as he can get the job done on the ground or in the air. He is a main focal point in their offense. George Kittle is also listed as questionable, as the 49er's star tight end still hasn't played this season.

On defense, the 49ers have been great. They are currently allowing 13 points per game and 210 total yards. This is the third least amount of points given up per game and the least amount of yards. The Seahawks and the Bears struggled to move the ball against them. They were especially good against the run, as they are only allowing 67.5 rushing yards per game. Their front seven and linebackers have been rallying to the ball with some speed to begin the season. This is also the second least amount of rushing yards allowed per game. Now, the San Francisco secondary has been solid, as well. They are only allowing 142.5 passing yards per game, which is also the least in the league. Moving the ball against the 49ers has been a challenge this season. I would also watch for Nick Bosa, as he will be looking to put some pressure on Russell Wilson and the Broncos. He has already recorded three sacks this season.

Are the Broncos Bad?

The Denver Broncos have had a slow start to the 2022 NFL season, as they have been horrible in the red zone. They have shown that they can move the ball, but they aren't cashing in for points. Denver is currently scoring 16 points per game and averaging 391.5 yards. This is the 24th most points scored per game and the seventh most yards. They will also look to get the ball to Javonte Williams, as he has been the leading back for the Broncos this season. He is averaging 5.4 yards per carry. Denver is also averaging 126 rushing yards per game, which is the 10th most in the NFL. They are throwing for 265.5 passing yards per game, as this is the eighth most. They have multiple wide receivers that can get the job done and Russel Wilson has shown that he is a capable QB in this league. Watch for him to get the ball to Courtland Sutton, as he has been Wilson's number one target. He has already recorded 194 yards this season, as he has been a threat in the middle of the field. Jerry Jeudy is still listed as questionable for this game with a shoulder injury. The Broncos are also yet to score in the red zone this season. They have shown they can consistently move the ball, but they aren't scoring nearly enough points.

On defense, the Broncos have been solid. They held the Texans to just nine points, as they continued to pressure Mills and they were impressive against the run. The Broncos are currently surrendering 13 points per game, which is tied with the 49ers for the third least. They are also allowing 243.5 yards per game, as this is the third least in the NFL. Moving the ball has been a challenge for their opponents this season. They will, unfortunately, be without Justin Simmons in this game, as he is currently injured. Caden Sterns will most likely take his spot at the safety position. Denver has still been solid against the pass without him, as they are only allowing 165.5 passing yards per game. This is the fifth least as Denver will desperately need Pat Surtain to be back for this game. He is their number one defensive back this season. They are also allowing the fifth least amount of rushing yards, as they are only surrendering 78 yards per game.

Best Bets for this Game

Full-Game Side Bet

Insiders Status:


I will be hammering the San Francisco 49ers (-1.5) in this matchup with the Denver Broncos on Sunday night. The 49er's defense has shown that they are legit this season, as they absolutely shut down the Seahawks in week 2. They are also great against the run and the pass, as they will be able to slow down Denver's rushing and passing attack. Nick Bosa will also leave his fingerprints all over this game, as the Denver offensive line has been shaky to begin the season. The 49ers are also allowing the least amount of yards per game, with 210. The Broncos will have multiple three an outs and they won't be able to give themselves enough opportunities to score. I also see them struggling in the red zone against this 49er's defense.

This will allow Garoppolo and the 49er's offense to slowly pull away. Denver's linebackers have not been good this season, as they struggle to defend the pass and the run. Denver will also be without Justin Simmons in this one and Jeudy is listed as questionable. This will hurt the Broncos on offense and defense, as they will struggle to defend the pass without Simmons. I also expect the 49ers to air it out more with Garoppolo starting at QB. He will get the ball to his playmakers and they will make enough plays to get the job done in this one. Denver is banged up and they are horrible in the red zone. They won't score enough points to keep this game competitive.

Hammer the 49ers and lay the points (-1.5).

Prediction: San Francisco 49ers -1.5

Full-Game Total Pick

Insiders Status:


I will be hammering the under (45) points in this game. These are two of the best defensive teams in the league and I see them making it very difficult for the opposing team to score. This is going to be a low-scoring defensive battle, as I don't trust either team to score a bunch of points in this game. The 49ers love to run the ball, but I see that being a struggle at different parts of this game. The Broncos are allowing the fifth least amount of rushing yards per game, as they shut down the Seahawks and the Texans running backs in back-to-back weeks. They will now make it difficult for the 49ers, as they will have to trust Garoppolo's arm to score some points. San Francisco is also only scoring the 19th most points. Denver has also struggled to get the ball in the end zone, as they are scoring the 24th most points per game. This 49ers' defense is also legit, as they will be able to keep the Broncos off the scoreboard for the majority of this game. I see a ton of field goals being kicked in this one, as both defenses will lock up in the red zone.

Take the under (45) points and expect both of these defenses to be the story in this one.

Prediction: Under 45

Written By Mason Folz , "Mason Folz"

Mason graduated from the University of Colorado, Boulder and he has been watching SportsCenter since before he could walk. He has been crunching numbers since he could learn to count and nothing makes Mason happier in this world than talking sports, unless he is on the golf course! We are very happy to have added Mason to our team at StatSalt and you will be glad as well. Let's win some money!