Prediction, Preview, and Odds
#471 Indianapolis Colts vs.
#472 Tennessee Titans
Sunday, September 26, 2021 at 1:00pm EDT
Nissan Stadium, Nashville
Written by Nick Raffoul

The Indianapolis Colts will head to Nissan Stadium on Sunday afternoon for an AFC South showdown against the division-rival Tennessee Titans.

Indianapolis comes into Week 3 as one of just six winless teams in the NFL. The Colts are off to an 0-2 start of the first time in head coach Frank Reich’s four-year tenure. Meanwhile, Tennessee avoided a winless start by stunning the Seattle Seahawks in overtime in Week 2.

Can the Titans build on their first win of the season with a win at home against the Colts on Sunday afternoon?

Wentz battling ankle injuries ahead of Week 3

Indianapolis came up short at home 27-24 in a hard-fought battle at home against the Los Angeles Rams. Carson Wentz completed 20-of-31 passes for 247 yards with one touchdown and one interception before watching the Colts’ final two possessions from the sidelines. Wentz left the game due to an ankle injury and did not return but backup Jacob Eason was unable to complete the comeback. Zach Pascal caught the lone touchdown of the day for the offense, his third touchdown of the season.

Wentz, who apparently sprained both of his ankles, was apparently feeling better but did not practice on Wednesday. The Colts are preparing to play both Eason and Brett Hundley if Wentz cannot play on Sunday. Through two games, Wentz has completed 65 percent of his passes for 498 yards with three touchdowns and one interception.

The Colts’ quarterbacks haven’t been able to get much from their ground game yet this year either. Jonathan Taylor leads the team in rushing with 107 yards but is averaging a pedestrian 3.3 yards per carry.

On defense, the Colts haven’t been nearly as stingy as in recent seasons, especially against the run. Indianapolis has given up 27.5 points and 386.5 yards of total offense per game this year. They’ve also been vulnerable against the run, allowing 120.5 rushing yards per game.

Henry carries Titans to OT-win against Seattle

Tennessee pulled off a late comeback to beat the Seattle Seahawks 33-30 in overtime last weekend. Derrick Henry rushed for 182 yards and three touchdowns and Ryan Tannehill orchestrated a 14-point fourth-quarter comeback to help the Titans emerge with their first win of the year. Tennessee racked up 532 yards of total offense and Julio Jones finished with his first 100-yard game in a Titans’ uniform, racking up

Tannehill has been off to a slow start under center but he picked things up in the second half last week. Through two games, the Titans’ quarterback has completed 64 percent of his passes for 559 yards with only one touchdown and one interception. The good news for Tennessee is that it was able to get Henry going against the Seahawks. After getting bottled up versus Arizona in the season-opener, Henry came through with a vintage performance, racking up 237 yards from scrimmage to carry the load on offense.

On defense, the Titans have given up 34 points per game and 422.5 yards of total offense per contest. Tennessee’s secondary has been picked apart through two games. They come in giving 300 yards per game through up the air, the fifth-worst mark in the NFL.

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Full-Game Side Bet

Insiders Status:


Indianapolis will take the field on Sunday in hopes of avoiding an 0-3 start but that might be a tough task if Wentz is unable to suit up under center. Fresh off of an impressive win against the Seahawks, Tennessee should be able to notch another win here. Look for Titans’ bruiser Derrick Henry to have another big game on Sunday. He had 182 rushing yards last week and 178 yards and three touchdowns in his last game against the Colts. With Jones and Brown on the outside, defenses are going to be hard-pressed to stack the box against Tennesee this season. Take the Titans to cover the spread on the road in this matchup on Sunday afternoon. 

Prediction: Tennessee Titans -5

Full-Game Total Pick

Insiders Status:


These two teams are projected for 48 points but that number seems a bit too high in this spot. Indianapolis hasn’t fared well on offense even with Wentz healthy and things could take a turn for the worse if Eason or Hundley is under center this week. Meanwhile, Tennessee has scored just 23 points per game through two games and the Titans will likely look to control the clock if things get out of hand in this one. Take this game to stay under the projected total in Tennesee on Sunday afternoon.

Prediction: Under 48

Written By Nick Raffoul , "Nick Raffoul"

Shortly after graduating with an Honors in Business Administration, Nick turned his attention from traditional stocks and bonds to investing in the performance of sports teams. He has been a very successful sports bettor over the years and has now brought his talents to us here at Winners & Whiners. Nick uses a combination of advanced stats and historical data to create sports investment models to identify value and generate consistent profits. Let Nick win for you.